About 4 results found for searched term "Cereblon inhibitor 2" (0.189 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43410 | Cereblon inhibitor 2 | E3 Ligase Ligand-Linker Conjugates |
| Cereblon inhibitor 2 is a Cereblon inhibitor useful in solid tumor research, especially breast cancer. | ||
| M13398 | BSJ-03-204 | PROTAC |
| BSJ-03-204 is a Cereblon ligand linked to THE CDK ligand PROTAC, which is an effective, selective cdK4/6 dual inhibitor based on Palbociclib. The IC50 of CDK4/D1 and CDK6/D1 were 26.9 nM and 10.4 nM, respectively. | ||
| M29314 | PROTAC Mcl1 degrader-1 | PROTAC |
| PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC50 of 0.54 μM. | ||
| M29518 | TD-428 | PROTAC |
| TD-428 is a PROTAC connected by ligands for Cereblon and BRD4. TD-428 is a highly specific BRD4 degrader with a DC50 of 0.32 nM. TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD-428 efficiently induce BET protein degradation. | ||
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